Chan W K, Wong Y W, Ding Y, Chua L P, Yu S C M
School of Mechanical and Production Engineering, Nanyang Technological University, Singapore, Republic of Singapore.
Artif Organs. 2002 Sep;26(9):785-93. doi: 10.1046/j.1525-1594.2002.06954.x.
Fluid dynamic forces in centrifugal blood pump impellers are of key importance in destruction of red blood cells (RBCs) because high rotational speed leads to strong interaction between the impeller and the RBCs. In this paper, three-dimensional models of five different blade geometries are investigated numerically using the commercial software CFX-TASCflow, and the streaklines of RBCs are obtained using the Lagrangian particle tracking method. In reality, RBCs pass through the pump along complicated paths resulting in a highly irregular loading condition for each RBC. In order to enable the prediction of blood damage under the action of these complex-loading conditions, a cumulative damage model for RBCs was adopted in this paper. The numerically simulated percent hemoglobin (%HB) released as RBCs traversed the impeller and volute was examined. It was observed that the residence time of particles in the blade passage is a critical factor in determining hemolytic effects. This, in turn, is a function of the blade geometry. In addition, it was observed that the volute profile is an important influence on the computed HB% released.
离心式血泵叶轮中的流体动力对于红细胞(RBC)的破坏至关重要,因为高转速会导致叶轮与红细胞之间的强烈相互作用。在本文中,使用商业软件CFX-TASCflow对五种不同叶片几何形状的三维模型进行了数值研究,并使用拉格朗日粒子跟踪方法获得了红细胞的流线。在实际情况中,红细胞沿着复杂路径通过血泵,导致每个红细胞承受高度不规则的负载条件。为了能够预测在这些复杂负载条件下的血液损伤,本文采用了红细胞累积损伤模型。研究了红细胞穿过叶轮和蜗壳时数值模拟得到的血红蛋白释放百分比(%HB)。观察到颗粒在叶片通道中的停留时间是决定溶血效应的关键因素。这反过来又是叶片几何形状的函数。此外,还观察到蜗壳轮廓对计算得到的HB%释放有重要影响。