内源性祖细胞介导的脑修复
Brain repair by endogenous progenitors.
作者信息
Kruger Genevieve M, Morrison Sean J
机构信息
Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA.
出版信息
Cell. 2002 Aug 23;110(4):399-402. doi: 10.1016/s0092-8674(02)00899-1.
Abstract
Stem cells within the adult brain can be stimulated by injury and growth factor treatment to replace damaged neurons, even neurons that are not normally generated in adults. Coupled with recent insights into the mechanism by which Nogo inhibits axonal regeneration, this discovery may inspire new treatments for central nervous system injuries and neurodegenerative diseases.
摘要
成体大脑中的干细胞可通过损伤和生长因子治疗来刺激，以替代受损神经元，甚至是成体中通常不会产生的神经元。结合最近对Nogo抑制轴突再生机制的见解，这一发现可能会激发针对中枢神经系统损伤和神经退行性疾病的新疗法。
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