Melville G N, Iravani J
Can J Physiol Pharmacol. 1975 Dec;53(6):1122-8. doi: 10.1139/y75-156.
The influence of drugs on ciliary beat frequency in the intrapulmonary airways of rats was studied in vitro. Sympathomimetic drugs significantly increased the ciliary beat frequency. Acetylcholine, pilocarpine, aminophylline, prednisolone, potassium iodide, and ammonium chloride also caused cilioexcitation, though to a lesser degree. Phentolamine, 5-hydroxytryptamine, histamine, and acetylcysteine caused an apparent cilioinhibition. However, histamine in high doses also caused an incoordination of ciliary beat. Codeine and phenobarbital were slightly cilioexcitatory in low concentrations and ciliodepressive at higher concentrations.
在体外研究了药物对大鼠肺内气道纤毛搏动频率的影响。拟交感神经药显著增加了纤毛搏动频率。乙酰胆碱、毛果芸香碱、氨茶碱、泼尼松龙、碘化钾和氯化铵也引起纤毛兴奋，尽管程度较轻。酚妥拉明、5-羟色胺、组胺和乙酰半胱氨酸引起明显的纤毛抑制。然而，高剂量的组胺也会导致纤毛搏动不协调。可待因和苯巴比妥在低浓度时略有纤毛兴奋作用，在高浓度时则有纤毛抑制作用。
