从链霉菌属Go 40/10中分离得到的内酯II的合成及绝对构型

Synthesis and absolute configuration of lactone II isolated from Streptomyces sp. Go 40/10.

作者信息

Ueki T, Morimoto Y, Kinoshita T

机构信息

Department of Chekistry,Graduate School of Science, Osaka City University, Sugimoto-cho, Sumiyoshi-ku, Osaka 558-8585, Japan.

出版信息

Chem Commun (Camb). 2001 Sep 21(18):1820-1. doi: 10.1039/b104920h.

DOI:10.1039/b104920h

PMID:12240331

Abstract

All four possible stereoisomers of lactone II isolated from Streptomyces sp. Go 40/10, an autoregulator, have been efficiently synthesized in a stereoselective manner starting from (S)-malic acid and sorbic acid, and the absolute configuration was determined to be 2S, 3S, 9R, 10S.

摘要

从作为自调节因子的链霉菌属Go 40/10中分离出的内酯II的所有四种可能的立体异构体，已从(S)-苹果酸和山梨酸开始以立体选择性方式高效合成，并且其绝对构型被确定为2S、3S、9R、10S。