从链霉菌 RI051-SDHV6 中分离得到的苯乙酰化肽 JBIR-96。
A phenylacetylated peptide, JBIR-96, isolated from Streptomyces sp. RI051-SDHV6.
机构信息
Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
出版信息
J Nat Prod. 2011 May 27;74(5):1344-7. doi: 10.1021/np200054s. Epub 2011 Apr 14.
PMID:21491925
Abstract
Searching for metabolites from Streptomyces sp. RI051-SDHV6 resulted in the discovery of a novel peptide, JBIR-96 (1). The structure of 1 was established as an N-phenylacetylated pentapeptide involving a cysteic acid and a peptide lactone structure by extensive NMR and MS analyses. In addition, the absolute configuration of 1 was established by Marfey's and modified Mosher's methods.
摘要
从链霉菌 RI051-SDHV6 中寻找代谢产物，发现了一种新型肽 JBIR-96（1）。通过广泛的 NMR 和 MS 分析，确定 1 的结构为 N-苯乙酰化五肽，涉及半胱氨酸和肽内酯结构。此外，通过 Marfey 法和改进的 Mosher 法确定了 1 的绝对构型。
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