Millasseau S C, Kelly R P, Ritter J M, Chowienczyk P J
Department of Clinical Pharmacology, St. Thomas' Hospital, Centre for Cardiovascular Biology and Medicine, King's College London, Lambeth Palace Road, London SE1 7EH, UK.
Clin Sci (Lond). 2002 Oct;103(4):371-7. doi: 10.1042/cs1030371.
The stiffness of the aorta can be determined by measuring carotid-femoral pulse wave velocity (PWV(cf)). PWV may also influence the contour of the peripheral pulse, suggesting that contour analysis might be used to assess large artery stiffness. An index of large artery stiffness (SI(DVP)) derived from the digital volume pulse (DVP) measured by transmission of IR light (photoplethysmography) was examined. SI(DVP) was obtained from subject height and from the time delay between direct and reflected waves in the DVP. The timing of these components of the DVP is determined by PWV in the aorta and large arteries. SI(DVP) was, therefore, expected to provide a measure of stiffness similar to PWV. SI(DVP) was compared with PWV(cf) obtained by applanation tonometry in 87 asymptomatic subjects (21-68 years; 29 women). The reproducibility of SI(DVP) and PWV(cf) and the response of SI(DVP) to glyceryl trinitrate were assessed in subsets of subjects. The mean within-subject coefficient of variation of SI(DVP), for measurements at weekly intervals, was 9.6%. SI(DVP) was correlated with PWV(cf) ( r =0.65, P <0.0001). SI(DVP) and PWV(cf) were each independently correlated with age and mean arterial blood pressure (MAP) with similar regression coefficients: SI(DVP)=0.63+0.086 x age+0.042 x MAP ( r =0.69, P <0.0001); PWV(cf)=0.76+0.080 x age+0.053 x MAP ( r =0.71, P <0.0001). Administration of glyceryl trinitrate (3, 30 and 300 microg/min intravenous; each dose for 15 min) in nine healthy men produced similar changes in SI(DVP) and PWV(cf). Thus contour analysis of the DVP provides a simple, reproducible, non-invasive measure of large artery stiffness.
主动脉僵硬度可通过测量颈股脉搏波速度（PWV(cf)）来确定。脉搏波速度也可能影响外周脉搏的形态，这表明形态分析可用于评估大动脉僵硬度。我们研究了一种基于红外光透射测量（光电容积描记法）得到的数字容积脉搏（DVP）推导出来的大动脉僵硬度指数（SI(DVP)）。SI(DVP)是根据受试者身高以及DVP中直接波与反射波之间的时间延迟得出的。DVP这些成分的时间由主动脉和大动脉中的脉搏波速度决定。因此，预计SI(DVP)能提供一种与脉搏波速度类似的僵硬度测量方法。我们将87名无症状受试者（年龄21 - 68岁；女性29名）的SI(DVP)与通过压平式眼压计测得的PWV(cf)进行了比较。在部分受试者亚组中评估了SI(DVP)和PWV(cf)的可重复性以及SI(DVP)对硝酸甘油的反应。对于每周测量一次的SI(DVP)，受试者内平均变异系数为9.6%。SI(DVP)与PWV(cf)相关（r = 0.65，P < 0.0001）。SI(DVP)和PWV(cf)各自均与年龄和平均动脉血压（MAP）独立相关，且回归系数相似：SI(DVP)=0.63 + （0.086×年龄）+ （0.042×MAP）（r = 0.69，P < 0.0001）；PWV(cf)=0.76 + （0.080×年龄）+ （0.053×MAP）（r = 0.71，P < 0.0001）。对9名健康男性静脉注射硝酸甘油（3、30和300微克/分钟；每个剂量持续15分钟）后，SI(DVP)和PWV(cf)出现了类似的变化。因此，对DVP进行形态分析可提供一种简单、可重复的无创大动脉僵硬度测量方法。
