铜绿假单胞菌PAO菌株脂多糖缺陷型突变体对染料、去污剂和抗生素的敏感性。
Susceptibility of lipopolysaccharide-defective mutants of Pseudomonas aeruginosa strain PAO to dyes, detergents, and antibiotics.
作者信息
Kropinski A M, Chan L, Milazzo F H
出版信息
Antimicrob Agents Chemother. 1978 Mar;13(3):494-9. doi: 10.1128/AAC.13.3.494.
Abstract
Lipopolysaccharide-defective mutants of Pseudomonas aeruginosa strain PAO have been isolated on the basis of their resistance to lipopolysaccharide-specific bacteriophages. These mutants have been differentiated by their agglutination in NaCl and acriflavine, phage sensitivity, and chemical analysis of the lipopolysaccharides. The susceptibility of the wild-type strain and four mutants to a series of twenty-six agents, including dyes, detergents, antibiotics, and lysozyme, was examined. The roughest mutant (AK-43) exhibited increased susceptibility to sodium deoxycholate, hexadecylpyridinium chloride, benzalkonium chloride, ampicillin, penicillin G, erythromycin, colymycin, and polymyxin B. The role of cell envelope fractions in antibiotic resistance in P. aeruginosa is discussed.
摘要
基于对脂多糖特异性噬菌体的抗性，已分离出铜绿假单胞菌PAO菌株的脂多糖缺陷型突变体。这些突变体通过它们在氯化钠和吖啶黄中的凝集反应、噬菌体敏感性以及脂多糖的化学分析得以区分。检测了野生型菌株和四个突变体对包括染料、去污剂、抗生素和溶菌酶在内的一系列二十六种试剂的敏感性。最粗糙的突变体（AK - 43）对脱氧胆酸钠、十六烷基氯化吡啶、苯扎氯铵、氨苄青霉素、青霉素G、红霉素、黏菌素和多黏菌素B的敏感性增加。讨论了细胞包膜组分在铜绿假单胞菌抗生素抗性中的作用。
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