Lopez V, Ochs H D, Thuline H C, Davis S D, Wedgwood R J
J Pediatr. 1975 Feb;86(2):207-11. doi: 10.1016/s0022-3476(75)80469-0.
Antibody responses to bacteriophage phichi 174 were studied in 17 institutionalized patients with trisomy 21 and in six mentally retarded control patients with normal karyotype. Primary antibody response was significantly impaired in 11 of the 17 patients. Secondary immune response was normal in one, moderately impaired in seven, and very low in nine patients. Tertiary immunization further differentiated the two groups: those with moderately impaired secondary immune responses developed normal serum titers of predominantly IgG antibody; patients with low secondary immune responses had extemely impaired tertiary immune responses consisting mainly of serum IgM antibody.
对17名患有21三体综合征的机构收容患者和6名核型正常的智力迟钝对照患者研究了针对噬菌体φX174的抗体反应。17名患者中有11名的初次抗体反应显著受损。二次免疫反应在1名患者中正常，7名患者中中度受损，9名患者中非常低。三次免疫进一步区分了两组：二次免疫反应中度受损的患者产生了主要为IgG抗体的正常血清滴度；二次免疫反应低的患者三次免疫反应极度受损，主要由血清IgM抗体组成。
