人类对φX 174的免疫反应。5. 原发性胆汁性肝硬化中的初次和二次抗体产生。
Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis.
作者信息
Thomas H C, Holden R, Jones J V, Peacock D B
出版信息
Gut. 1976 Nov;17(11):844-8. doi: 10.1136/gut.17.11.844.
Abstract
In primary biliary cirrhosis, the primary immune response to the bacteriophage phi X 174 is normal but the secondary response is significantly reduced. The reduction is primarily of IgG antibody, while IgM is proportionately less affected. These changes may be the result of a reduction in helper T lymphocyte function and may contribute to the increase in the ratio of serum concentration of IgM to IgG.
摘要
在原发性胆汁性肝硬化中，对噬菌体φX 174的初次免疫反应正常，但二次反应显著降低。这种降低主要是IgG抗体的降低，而IgM受影响相对较小。这些变化可能是辅助性T淋巴细胞功能降低的结果，并且可能导致血清中IgM与IgG浓度比值的增加。
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