Hawkes R A, Boughton C R, Schroeter D R
Clin Exp Immunol. 1978 Feb;31(2):298-304.
An earlier cross-sectional study had revealed that institutionalized Down's syndrome (DS) patients possessed much lower titres of hepatitis B surface antibodies (anti-HBs) than did their non-Down's (ND) counterparts. In an attempt to determine whether DS patients were generally deficient in humoral antibody response, the inmates of an institution for the mentally retarded (110 DS, seventy-eight ND) were immunized with tetanus, diphtheria (toxoids), influenza A, influenza B (inactivated vaccines), measles, mumps and rubella (attenuated vaccines), and tested for their antibody responses. The DS and ND groups did not respond differently to any of the seven antigens. Furthermore, there was no general relationship between the anti-HBs titres of inmates and their capacity to respond to the defined antigenic stimulus of any of the seven antigens. From these results it is apparent that a general humoral deficit in the DS group cannot explain their tendency to possess much lower anti-HBs titres than their ND counterparts upon becoming infected with the hepatitis B virus. When the antibody status and responses to immunization of the inmates who possessed anti-HBs were compared with those who had chronic HBsAg antigenaemia, there was no significant difference between the groups.
一项较早的横断面研究显示，机构收容的唐氏综合征（DS）患者的乙型肝炎表面抗体（抗-HBs）滴度远低于非唐氏综合征（ND）患者。为了确定DS患者是否普遍存在体液抗体反应缺陷，一所智障机构的收容人员（110名DS患者、78名ND患者）接种了破伤风、白喉（类毒素）、甲型流感、乙型流感（灭活疫苗）、麻疹、腮腺炎和风疹（减毒活疫苗），并检测了他们的抗体反应。DS组和ND组对七种抗原中的任何一种的反应均无差异。此外，收容人员的抗-HBs滴度与他们对七种抗原中任何一种特定抗原刺激的反应能力之间没有普遍关系。从这些结果可以明显看出，DS组普遍存在的体液缺陷并不能解释他们在感染乙型肝炎病毒后抗-HBs滴度远低于ND组的倾向。当比较有抗-HBs的收容人员与患有慢性HBsAg抗原血症的收容人员的抗体状态和免疫反应时，两组之间没有显著差异。
