Chen Honglei, Ward Mary H, Tucker Katherine L, Graubard Barry I, McComb Rodney D, Potischman Nancy A, Weisenburger Dennis D, Heineman Ellen F
Tufts University, Human Nutrition Research Center on Aging, Boston, MA, USA.
Cancer Causes Control. 2002 Sep;13(7):647-55. doi: 10.1023/a:1019527225197.
To investigate potential associations between diet and adult glioma.
We conducted a population-based case-control study of adult glioma in eastern Nebraska. Nutrient and food group intakes were estimated for 236 glioma cases and 449 controls using information obtained from a food-frequency questionnaire.
After adjusting for potential confounders, inverse associations with risk of adult glioma were observed for intakes of dark yellow vegetables (highest quartile versus lowest: OR = 0.6, Ptrend = 0.03) and beans (OR = 0.4, Ptrend = 0.0003), but no associations were seen for dietary sources of preformed nitrosamines or high-nitrate vegetables. Our nutrient analysis revealed significant inverse associations between risk of adult glioma and dietary intake of pro-vitamin A carotenoids (highest quartile versus lowest: OR = 0.5, Ptrend = 0.005), a-carotene (OR = 0.5, Ptrend = 001), beta-carotene (OR = 0.5, Ptrend = 0.01), dietary fiber (OR=0.6, Ptrend = 0.048) and fiber from beans (OR = 0.5, Ptrend = 0.0002). We observed no significant associations with risk of adult glioma for intakes of other nutrients or compounds including nitrate, nitrite, vitamin C, vitamin E, saturated fat, cholesterol, dietary fiber from grain products, or fiber from fruit and vegetables.
Our study does not support the N-nitroso compound hypothesis, but suggests potential roles for carotenoids and possibly other phytochemicals in reducing risk of adult glioma.
研究饮食与成人胶质瘤之间的潜在关联。
我们在 Nebraska 东部开展了一项基于人群的成人胶质瘤病例对照研究。利用食物频率问卷获得的信息，估算了 236 例胶质瘤病例和 449 例对照的营养素和食物组摄入量。
在对潜在混杂因素进行调整后，发现摄入深黄色蔬菜（最高四分位数与最低四分位数相比：OR = 0.6，P趋势 = 0.03）和豆类（OR = 0.4，P趋势 = 0.0003）与成人胶质瘤风险呈负相关，但未发现预制亚硝胺或高硝酸盐蔬菜的饮食来源与成人胶质瘤风险存在关联。我们的营养素分析显示，成人胶质瘤风险与维生素A原类胡萝卜素的饮食摄入量（最高四分位数与最低四分位数相比：OR = 0.5，P趋势 = 0.005）、α-胡萝卜素（OR = 0.5，P趋势 = 0.01）、β-胡萝卜素（OR = 0.5，P趋势 = 0.01）、膳食纤维（OR = 0.6，P趋势 = 0.048）和豆类纤维（OR = 0.5，P趋势 = 0.0002）呈显著负相关。对于其他营养素或化合物的摄入量，包括硝酸盐、亚硝酸盐、维生素C、维生素E、饱和脂肪、胆固醇、谷物产品中的膳食纤维或水果和蔬菜中的膳食纤维，我们未观察到与成人胶质瘤风险存在显著关联。
我们的研究不支持N-亚硝基化合物假说，但表明类胡萝卜素以及可能的其他植物化学物质在降低成人胶质瘤风险方面可能发挥作用。
