Lier B B, Rösing C K, Aass A M, Gjermo P
Department of Periodontology, Faculty of Dentistry, University of Oslo, Norway.
J Clin Periodontol. 2002 Jun;29(6):501-6. doi: 10.1034/j.1600-051x.2002.290605.x.
BACKGROUND, AIMS: Promising results using Nd:YAG laser against dentin hypersensitivity have been reported. The aim of this double-blind, controlled, split-mouth designed clinical trial was to assess the effect of a single Nd:YAG laser application on alleviating hypersensitivity.
METHODS/RESULTS: Seventeen subjects participated in the study. Each of them had two teeth treated; one with the laser activated and one with nonactivated (placebo), for 2 min The assessment of pain was performed by a VAS, after an air blast at baseline immediately after treatment, at 1 week, 4 weeks and 16 weeks. Mean values of VAS for test and control teeth were compared by paired t-test (alpha = 0.05). The results showed mean baseline VAS values of 6.59 (+/- 1.65) and 6.14(+/- 1.95) for test and control teeth, respectively. Immediately after treatment, these values decreased to 4.09(+/- 2.28) and 3.89(+/- 2.11), respectively. After 1 week, 4 weeks and 16 weeks the mean values for test and control teeth were 3.85 +/- 2.36, 4.03 +/- 1.95, 3.60 +/- 2.66, and 4.44 +/- 2.56, 3.41 +/- 2.30, 3.42 +/- 2.30, respectively. There were no statistically significant differences between test and control at any time. However, both groups improved significantly (P < 0.05) from baseline to immediately after application, and at 1 week, 4 weeks and 16 weeks, respectively. The changes that occurred between immediately after application and 1 week, 4 weeks and 16 weeks, respectively, were not statistically significant.
It is concluded that the effect of treatment of hypersensitive teeth with Nd:YAG laser is not different from placebo. The observed effects seem to last for at least 16 weeks.
已有报道称使用钕钇铝石榴石（Nd:YAG）激光治疗牙本质过敏取得了有前景的结果。这项双盲、对照、半口设计的临床试验的目的是评估单次Nd:YAG激光照射对缓解过敏的效果。
17名受试者参与了该研究。他们每人有两颗牙齿接受治疗；一颗接受激光照射，另一颗接受未激活（安慰剂）照射，持续2分钟。在基线、治疗后立即、1周、4周和16周进行气枪刺激后，通过视觉模拟评分法（VAS）评估疼痛。通过配对t检验（α = 0.05）比较试验组和对照组牙齿的VAS平均值。结果显示，试验组和对照组牙齿的基线VAS平均值分别为6.59（±1.65）和6.14（±1.95）。治疗后立即，这些值分别降至4.09（±2.28）和3.89（±2.11）。1周、4周和16周后，试验组和对照组牙齿的平均值分别为3.85±2.36、4.03±1.95、3.60±2.66和4.44±2.56、3.41±2.30、3.42±2.30。在任何时间，试验组和对照组之间均无统计学显著差异。然而，两组在治疗后立即、1周、4周和16周时均较基线有显著改善（P < 0.05）。在治疗后立即与1周、4周和16周之间发生的变化无统计学显著意义。
得出结论，用Nd:YAG激光治疗过敏牙齿的效果与安慰剂无异。观察到的效果似乎至少持续16周。
