Cheigh J S, Stenzel K H, Riggio R R, Katz E B, Rubin A L
Transplant Proc. 1975 Mar;7(1):31-5.
Mixed-lymphocyte-culture response and peripheral lymphocyte counts were determined after 100 mg and 1,000 mg of methylprednisolone were administered intravenously to healthy volunteers; The MLC response was significantly suppressed in both groups for at least 12 hr. The degree of suppression of the MLC response did not differ between the two groups. Lymphocytopenia persisted for at least 24 hr. The MLC response, however, returned to its full capacity within 24 hr. In the low-dose group this response showed a marked rebound phenomenon at 24 hr. These findings indicate that methylprednisolone has a profound inhibitory effect on lymphoid cells' response to allogenic stumli in the MLC system.
对健康志愿者静脉注射100毫克和1000毫克甲泼尼龙后，测定混合淋巴细胞培养反应和外周淋巴细胞计数；两组的混合淋巴细胞培养反应均被显著抑制至少12小时。两组间混合淋巴细胞培养反应的抑制程度无差异。淋巴细胞减少持续至少24小时。然而，混合淋巴细胞培养反应在24小时内恢复到完全能力。在低剂量组，这种反应在24小时时出现明显的反弹现象。这些发现表明，甲泼尼龙对混合淋巴细胞培养系统中淋巴细胞对同种异体刺激的反应具有深远的抑制作用。
