Rosenberg J C, Colburn W A, Brennan P, Lysz K, Palutke M, Stubbs S S, Rosenberg S A
Transplant Proc. 1975 Dec;7(4):547-56.
Technics of studying the protein synthesis of canine thymus-derived lymphocytes in vitro have been developed. Activation of these cells by PHA or MLC increases protein synthesis. Methylprednisolone decreases the stimulation of protein synthesis of these activated lymphocytes. The decrease in protein synthesis is not caused by lympholysis. In this respect, the dog, like man, can be considered a steroid-resistant animal. It is postulated that this effect of methylprednisolone contributes to its immunosuppressive action by inhibiting the afferent limb of the immune response.
已开发出体外研究犬胸腺来源淋巴细胞蛋白质合成的技术。PHA或MLC对这些细胞的激活会增加蛋白质合成。甲基强的松龙会降低这些活化淋巴细胞蛋白质合成的刺激。蛋白质合成的减少不是由淋巴细胞溶解引起的。在这方面，狗和人一样，可以被认为是一种对类固醇耐药的动物。据推测，甲基强的松龙的这种作用通过抑制免疫反应的传入支而有助于其免疫抑制作用。
