药物代谢随年龄增长的变化：1. 华法林与血浆蛋白的结合
Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins.
作者信息
Hayes M J, Langman M J, Short A H
出版信息
Br J Clin Pharmacol. 1975 Feb;2(1):69-72. doi: 10.1111/j.1365-2125.1975.tb00474.x.
Abstract
1 A decrease was found in the binding capacity of elderly people for warfarin. 2 The decrease in binding correlated with a fall in plasma albumin concentrations. 3 No changes in the association constant were observed.
摘要
发现老年人对华法林的结合能力有所下降。
结合能力的下降与血浆白蛋白浓度的降低相关。
未观察到结合常数的变化。
相似文献
1
Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins.药物代谢随年龄增长的变化：1. 华法林与血浆蛋白的结合
Br J Clin Pharmacol. 1975 Feb;2(1):69-72. doi: 10.1111/j.1365-2125.1975.tb00474.x.
2
In vitro effect of Cl2Ca and Cl2Mg on warfarin-human serum albumin (HSA) binding.氯化钙和氯化镁对华法林-人血清白蛋白（HSA）结合的体外作用。
Magnes Res. 1999 Mar;12(1):43-8.
3
Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.药物代谢随年龄增长的变化：2. 苯妥英钠清除率与蛋白结合率
Br J Clin Pharmacol. 1975 Feb;2(1):73-9. doi: 10.1111/j.1365-2125.1975.tb00475.x.
4
Intersubject variation of warfarin binding to protein in serum of normal subjects.正常受试者血清中华法林与蛋白质结合的个体间差异。
Res Commun Chem Pathol Pharmacol. 1976 Aug;14(4):743-6.
5
Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro.药用级白蛋白：体外药物结合能力受损。
BMC Clin Pharmacol. 2004 Mar 29;4:4. doi: 10.1186/1472-6904-4-4.
6
Binding of piroxicam to human serum albumin: effect of piroxicam on warfarin and diazepam binding.吡罗昔康与人血清白蛋白的结合：吡罗昔康对华法林和地西泮结合的影响。
Pharm Res. 1987 Aug;4(4):355-7. doi: 10.1023/a:1016413707845.
7
Binding of warfarin by human albumin in the presence of a perfluorochemical blood substitute.在全氟化合物血液代用品存在的情况下华法林与人血清白蛋白的结合。
Arch Int Pharmacodyn Ther. 1985 Sep;277(1):4-14.
8
Antipyrine and warfarin disposition in a patient with idiopathic hypoalbuminemia.
Clin Pharmacol Ther. 1981 Dec;30(6):810-6. doi: 10.1038/clpt.1981.242.
9
Interaction of warfarin with human serum albumin. A stoichiometric description.华法林与人类血清白蛋白的相互作用。一种化学计量学描述。
Mol Pharmacol. 1985 Feb;27(2):263-70.
10
Effect of variation of plasma oleic acid concentration on relative concentration of free and protein bound warfarin.血浆油酸浓度变化对游离及蛋白结合型华法林相对浓度的影响
J Pharm Sci. 1981 Jan;70(1):114-5. doi: 10.1002/jps.2600700133.
引用本文的文献
1
Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin.成人年龄对（R）-和（S）-华法林总清除率、游离清除率和蛋白结合率的影响。
Br J Clin Pharmacol. 2012 Nov;74(5):797-805. doi: 10.1111/j.1365-2125.2012.04259.x.
2
Venous thromboembolism in patients with membranous nephropathy.膜性肾病患者的静脉血栓栓塞症。
Clin J Am Soc Nephrol. 2012 Jan;7(1):43-51. doi: 10.2215/CJN.04250511. Epub 2011 Nov 10.
3
Cardiovascular drug therapy in the elderly: theoretical and practical considerations.老年人的心血管药物治疗：理论与实践考量
Drugs Aging. 2003;20(6):445-63. doi: 10.2165/00002512-200320060-00004.
4
Disposition of antipyrine and phenytoin correlated with age and liver volume in man.安替比林和苯妥英在人体内的处置与年龄及肝脏体积相关。
Clin Pharmacokinet. 1981 Sep-Oct;6(5):389-96. doi: 10.2165/00003088-198106050-00005.
5
Altered plasma protein binding of drugs in thyroid disease.甲状腺疾病中药物血浆蛋白结合的改变。
Clin Pharmacokinet. 1981 Jul-Aug;6(4):298-305. doi: 10.2165/00003088-198106040-00004.
6
The effect of age on the pharmacokinetics of metoprolol and its metabolites.年龄对美托洛尔及其代谢产物药代动力学的影响。
Br J Clin Pharmacol. 1981 Mar;11(3):287-94. doi: 10.1111/j.1365-2125.1981.tb00536.x.
7
Pethidine binding to blood cells and plasma proteins in old and young subjects.哌替啶在老年和青年受试者中与血细胞及血浆蛋白的结合情况。
Eur J Clin Pharmacol. 1982;23(5):457-61. doi: 10.1007/BF00605998.
8
Effect of age and sex on the plasma binding of acidic and basic drugs.年龄和性别对酸性及碱性药物血浆蛋白结合率的影响。
Eur J Clin Pharmacol. 1984;27(1):91-7.
9
The influence of age, smoking and hyperthyroidism on plasma propranolol steady state concentration.年龄、吸烟和甲状腺功能亢进对血浆普萘洛尔稳态浓度的影响。
Br J Clin Pharmacol. 1981 Jul;12(1):73-8. doi: 10.1111/j.1365-2125.1981.tb01857.x.
10
Salicylate protein binding in serum from young and elderly subjects as measured by diafiltration.
Eur J Clin Pharmacol. 1985;28(3):339-45. doi: 10.1007/BF00543334.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The plasma protein pattern and its significance in geriatrics and cancer diagnosis.血浆蛋白图谱及其在老年医学和癌症诊断中的意义。
Geriatrics. 1955 May;10(5):232-8.
3
The significance of haemorrhage during the treatment of patients with the coumarin anticoagulants.
Acta Med Scand Suppl. 1958;339:1-62. doi: 10.1111/j.0954-6820.1958.tb17330.x.
4
Electrophoretic studies on the serum of normal aged individuals.对正常老年人血清的电泳研究。
Am J Med Sci. 1952 Nov;224(5):522-8. doi: 10.1097/00000441-195211000-00007.
5
Studies on the coumarin anticoagulant drugs: interaction of human plasma albumin and warfarin sodium.香豆素类抗凝药物的研究：人血浆白蛋白与华法林钠的相互作用
J Clin Invest. 1967 May;46(5):829-37. doi: 10.1172/JCI105582.
6
The determination of human serum albumin by its specific binding of the anionic dye, 2-(4'-hydroxybenzeneazo)-benzoic acid.通过阴离子染料2-（4'-羟基苯偶氮）苯甲酸的特异性结合来测定人血清白蛋白。
Clin Chim Acta. 1965 Nov;12(5):532-41. doi: 10.1016/0009-8981(65)90168-3.
7
Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin.抗凝药华法林及其代谢产物与人血浆白蛋白的相互作用。
J Clin Invest. 1969 Jan;48(1):193-202. doi: 10.1172/JCI105968.
8
Predisposing factors in adverse reactions to drugs.药物不良反应的诱发因素。
Br Med J. 1969 Mar 1;1(5643):536-9. doi: 10.1136/bmj.1.5643.536.
9
Serum protein in an aging population with particular reference to evaluation of immune globulins and antibodies.老年人群中的血清蛋白，特别涉及免疫球蛋白和抗体的评估。
Gerontologia. 1966;12(1):30-6. doi: 10.1159/000211530.
Zotero 插件