Ma Wenhui, Ma Xiaolin, Huang Hai, Zhou Pei, Chen Daofeng
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, PR China.
Chem Biodivers. 2007 May;4(5):966-72. doi: 10.1002/cbdv.200790087.
Two new dibenzocyclooctane lignans, kadsurindutins A (1) and B (2), were isolated from the stems of Kadsura induta, together with the known, structurally related lignans schisantherin L (3), schisantherin P (4), kadsulignan L (5), and neokadsuranin (6). Their structures and configurations were elucidated by spectroscopic methods (UV, ORD, CD, IR, 1D- and 2D-NMR) in combination with mass-spectrometric (HR-MS) techniques. Compounds 1, 5, and 6 showed in vitro antiviral effects on hepatitis B virus.
从披针叶南五味子茎中分离得到两个新的二苯并环辛烷木脂素，南五味子双酯甲（1）和南五味子双酯乙（2），以及结构相关的已知木脂素五味子酯L（3）、五味子酯P（4）、南五味子木脂素L（5）和新五味子素（6）。通过光谱方法（紫外光谱、旋光色散、圆二色光谱、红外光谱、一维和二维核磁共振）结合质谱（高分辨质谱）技术确定了它们的结构和构型。化合物1、5和6对乙型肝炎病毒显示出体外抗病毒活性。
