黑老虎茎中的二苯并环辛烷木脂素及其对乙型肝炎病毒的抗病毒作用。
Dibenzocyclooctane lignans from the stems of Kadsura induta and their antiviral effect on hepatitis B virus.
作者信息
Ma Wenhui, Ma Xiaolin, Huang Hai, Zhou Pei, Chen Daofeng
机构信息
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, PR China.
出版信息
Chem Biodivers. 2007 May;4(5):966-72. doi: 10.1002/cbdv.200790087.
Two new dibenzocyclooctane lignans, kadsurindutins A (1) and B (2), were isolated from the stems of Kadsura induta, together with the known, structurally related lignans schisantherin L (3), schisantherin P (4), kadsulignan L (5), and neokadsuranin (6). Their structures and configurations were elucidated by spectroscopic methods (UV, ORD, CD, IR, 1D- and 2D-NMR) in combination with mass-spectrometric (HR-MS) techniques. Compounds 1, 5, and 6 showed in vitro antiviral effects on hepatitis B virus.
从披针叶南五味子茎中分离得到两个新的二苯并环辛烷木脂素，南五味子双酯甲（1）和南五味子双酯乙（2），以及结构相关的已知木脂素五味子酯L（3）、五味子酯P（4）、南五味子木脂素L（5）和新五味子素（6）。通过光谱方法（紫外光谱、旋光色散、圆二色光谱、红外光谱、一维和二维核磁共振）结合质谱（高分辨质谱）技术确定了它们的结构和构型。化合物1、5和6对乙型肝炎病毒显示出体外抗病毒活性。
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