Ballin Nicolai Zederkopff, Traore Maminata, Tinto Halidou, Sittie Archibald, Mølgaard Per, Olsen Carl Erik, Kharazmi Arsalan, Christensen Søren Brøgger
Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
J Nat Prod. 2002 Sep;65(9):1325-7. doi: 10.1021/np020008h.
Fractionation of an ethanol extract of roots of Cochlospermum tinctorium afforded five compounds: 3-O-E-p-coumaroylalphitolic acid (1), cochloxanthin (2), dihydrocochloxanthin (3), alphitolic acid (4), and 1-hydroxytetradecan-3-one (5). This is the first example of a 1-hydroxyalkan-3-one obtained from plant material after gentle workup. The antiplasmodial activities of the compounds were determined, and the IC(50) value of 3-O-E-p-coumaroylalphitolic acid was 2.3 microM.
