• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

奥昆多过氧化物,一种来自石龙尾的双环环芳基倍半萜内过氧化物,具有抗疟原虫活性。

Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.

机构信息

Department of Chemistry, University of Buea, PO Box 63, Buea, Southwest Province, Cameroon.

出版信息

J Nat Prod. 2009 Feb 27;72(2):280-3. doi: 10.1021/np800338p.

DOI:10.1021/np800338p
PMID:19199815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2765531/
Abstract

Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.

摘要

奥昆多过氧化物(1)是通过对大油芒(syn. 大油芒)提取物进行基于生物测定的分步分离而得到的。该化合物含有环状内过氧化物结构部分,具有中等的抗疟活性。

相似文献

1
Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.奥昆多过氧化物,一种来自石龙尾的双环环芳基倍半萜内过氧化物,具有抗疟原虫活性。
J Nat Prod. 2009 Feb 27;72(2):280-3. doi: 10.1021/np800338p.
2
Antimalarial activity of sesquiterpene lactones from Vernonia cinerea.灰叶斑鸠菊倍半萜内酯的抗疟活性。
Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1437-9. doi: 10.1248/cpb.54.1437.
3
Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux.基于生物测定的抗菌药物发现:梨果胡椒、斐氏石豆兰和条纹水蜈蚣的体外筛选。
Ann Clin Microbiol Antimicrob. 2012 May 1;11:10. doi: 10.1186/1476-0711-11-10.
4
Antimalarial activity of the isolates from the marine sponge Hyrtios erectus against the chloroquine-resistant Dd2 strain of Plasmodium falciparum.来自海洋海绵直立希氏海绵的分离物对恶性疟原虫氯喹抗性Dd2株的抗疟活性。
Z Naturforsch C J Biosci. 2018 Sep 25;73(9-10):397-400. doi: 10.1515/znc-2018-0025.
5
Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of 10,12-peroxycalamenene, a sesquiterpene endoperoxide.
Phytochemistry. 1995 Sep;40(1):125-8. doi: 10.1016/0031-9422(95)00260-e.
6
Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).从 Symphonia globulifera(藤黄科)的根皮中提取的抗疟苯并酮衍生物。
Phytochemistry. 2010 Jun;71(8-9):964-74. doi: 10.1016/j.phytochem.2010.03.008. Epub 2010 Mar 29.
7
Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae).硬鳞果薹草(莎草科)中倍半萜衍生物的存在情况。
Nat Prod Commun. 2009 Jan;4(1):5-8.
8
Brominated sesquiterpenes from the red alga Laurencia obtusa.来自红藻钝形凹顶藻的溴化倍半萜类化合物。
J Nat Prod. 2003 Nov;66(11):1505-8. doi: 10.1021/np030176p.
9
Indolosesquiterpene alkaloids from the Cameroonian medicinal plant Polyalthia oliveri (Annonaceae).来自喀麦隆药用植物奥利氏暗罗(番荔枝科)的吲哚倍半萜生物碱。
Phytochemistry. 2014 Sep;105:52-9. doi: 10.1016/j.phytochem.2014.06.015. Epub 2014 Jul 16.
10
Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima.来自全缘麻风树的二萜类化合物、倍半萜类化合物和一种倍半萜-香豆素共轭物。
J Nat Prod. 2009 Nov;72(11):2024-7. doi: 10.1021/np900342b.

引用本文的文献

1
Antimalarial Natural Products.抗疟天然产物。
Prog Chem Org Nat Prod. 2022;117:1-106. doi: 10.1007/978-3-030-89873-1_1.
2
In vitro antiplasmodial activity and prophylactic potentials of extract and fractions of Trema orientalis (Linn.) stem bark.山黄麻茎皮提取物及其各馏分的体外抗疟活性和预防潜力
BMC Complement Altern Med. 2017 Aug 15;17(1):407. doi: 10.1186/s12906-017-1914-x.
3
Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens.植物源抗菌剂对抗多重耐药性人类病原体。
3 Biotech. 2017 Jul;7(3):172. doi: 10.1007/s13205-017-0848-9. Epub 2017 Jun 29.
4
Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment.来自喀麦隆香料硬鳞苔草的抗寄生虫倍半萜及其体外和计算机辅助DMPK初步评估
Nat Prod Bioprospect. 2017 Jun;7(3):235-247. doi: 10.1007/s13659-017-0125-y. Epub 2017 Apr 18.
5
The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.来自非洲药用植物的抗疟化合物的潜力,第一部分:生物碱和萜类化合物的药理学评价。
Malar J. 2013 Dec 13;12:449. doi: 10.1186/1475-2875-12-449.
6
Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux.基于生物测定的抗菌药物发现:梨果胡椒、斐氏石豆兰和条纹水蜈蚣的体外筛选。
Ann Clin Microbiol Antimicrob. 2012 May 1;11:10. doi: 10.1186/1476-0711-11-10.
7
Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products.植物源抗疟药:新线索与高效植物药。第二部分。非生物碱类天然产物。
Molecules. 2009 Aug 13;14(8):3037-72. doi: 10.3390/molecules14083037.

本文引用的文献

1
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.用于测定手性甲醇碳绝对构型的莫舍尔酯分析。
Nat Protoc. 2007;2(10):2451-8. doi: 10.1038/nprot.2007.354.
2
Antiplasmodial marine natural products in the perspective of current chemotherapy and prevention of malaria: a review.从当前疟疾化疗与预防角度看抗疟海洋天然产物综述
Mar Biotechnol (NY). 2006 Sep-Oct;8(5):433-47. doi: 10.1007/s10126-006-6100-y. Epub 2006 Mar 30.
3
Identification of an antimalarial synthetic trioxolane drug development candidate.一种抗疟合成三氧杂环乙烷药物开发候选物的鉴定。
Nature. 2004 Aug 19;430(7002):900-4. doi: 10.1038/nature02779.
4
Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.
Acc Chem Res. 2004 Jun;37(6):397-404. doi: 10.1021/ar020227u.
5
Naturally occurring peroxides with biological activities.具有生物活性的天然过氧化物。
Mini Rev Med Chem. 2003 Mar;3(2):159-65. doi: 10.2174/1389557033405313.
6
Convergent enantioselective synthesis of the tricyclic core of phomactin A.佛手菌素A三环核心的对映选择性汇聚合成。
Org Lett. 2002 Jul 11;4(14):2413-6. doi: 10.1021/ol026159t.
7
A new route to diastereomerically pure cyclopropanes utilizing stabilized phosphorus ylides and gamma-hydroxy enones derived from 1, 2-dioxines: mechanistic investigations and scope of reaction.一种利用稳定的磷叶立德和源自1,2 -二氧六环的γ-羟基烯酮制备非对映体纯环丙烷的新方法:机理研究与反应范围
J Org Chem. 2000 Sep 8;65(18):5531-46. doi: 10.1021/jo0002240.
8
Peroxy natural products.过氧天然产物。
Nat Prod Rep. 1992 Aug;9(4):289-312. doi: 10.1039/np9920900289.
9
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.通过半自动微量稀释技术对体外抗疟活性进行定量评估。
Antimicrob Agents Chemother. 1979 Dec;16(6):710-8. doi: 10.1128/AAC.16.6.710.