小叶 Cedrelopsis 的生物活性成分。

Bioactive constituents of Cedrelopsis microfoliata.

作者信息

Koorbanally Neil A, Randrianarivelojosia Milijaona, Mulholland Dulcie A, Quarles van Ufford Linda, van den Berg Albert J J

机构信息

Natural Products Research Group, Department of Chemistry, University of Natal, Durban, 4041, South Africa.

出版信息

J Nat Prod. 2002 Sep;65(9):1349-52. doi: 10.1021/np0200562.

DOI:10.1021/np0200562

PMID:12350164

Abstract

The stem bark of Cedrelopsis microfoliata has yielded the new compounds microfolian (1), microfolione (2), and microfolicoumarin (6) along with the known compounds agrandol (3), cedrecoumarin A (4), obliquin (5), and sesquichamaenol (7). Compounds 2-4 were found to show agonistic activity on both alpha- and beta-estrogenic receptors, and compounds 1, 3, and 4 were shown to inhibit the chemiluminescence of reactive oxygen metabolites and showed superoxide scavenging activity.

摘要

小叶 Cedrelopsis 的茎皮产生了新化合物微叶酸（1）、微叶酸酮（2）和微叶酸香豆素（6），以及已知化合物阿格兰多（3）、雪松香豆素 A（4）、斜蒽醌（5）和倍半金合欢烯醇（7）。发现化合物 2 - 4 对α-和β-雌激素受体均表现出激动活性，并且化合物 1、3 和 4 显示出抑制活性氧代谢物的化学发光并表现出超氧化物清除活性。