Harley David, Bossingham David, Purdie David M, Pandeya Nirmala, Sleigh Adrian C
Developmental Disability Unit, School of Population Health, University of Queensland, Mater Hospital, Raymond Terrace, South Brisbane, QLD 4101, Australia.
Med J Aust. 2002 Oct 7;177(7):352-5. doi: 10.5694/j.1326-5377.2002.tb04836.x.
To describe the natural history of rheumatic manifestations of Ross River virus (RRV) disease.
Prospective longitudinal clinical review.
North Queensland local government areas of Cairns, Douglas, Mareeba and Atherton during January to May 1998.
General practice patients diagnosed with RRV disease on the basis of symptoms and a positive RRV IgM result.
Rheumatic symptoms and signs assessed as soon as possible after disease onset and on two subsequent occasions (up to 6.5 months after onset).
57 patients were recruited, 47 of whom were reviewed three times (at means of 1.1, 2.4 and 3.6 months after disease onset). Results are reported for these 47: 46 (98%) complained of joint pain at first review, with the ankles, wrists, fingers, knees and metacarpophalangeal joints (II-IV) most commonly involved. Prevalence of joint pain decreased progressively on second and third reviews, both overall (92% and 68% of patients, respectively), and in the five joints most commonly affected. The prevalence of other common rheumatic symptoms and signs, and use of non-steroidal anti-inflammatory drugs, also progressively declined over the three reviews.
Earlier studies may have overestimated the prevalence and duration of symptoms in RRV disease. Progressive resolution over 3-6 months appears usual.
描述罗斯河病毒（RRV）病风湿表现的自然病程。
前瞻性纵向临床回顾。
1998年1月至5月期间，位于北昆士兰的凯恩斯、道格拉斯、马雷巴和阿瑟顿等地方政府辖区。
根据症状及RRV IgM检测结果呈阳性而被诊断为RRV病的全科医疗患者。
在疾病发作后尽快以及随后两次（发作后长达6.5个月）评估风湿症状和体征。
招募了57名患者，其中47名接受了三次复查（疾病发作后平均1.1、2.4和3.6个月）。报告这47名患者的结果：首次复查时，46名（98%）主诉关节疼痛，最常受累的是踝关节、腕关节、手指关节、膝关节和掌指关节（II-IV）。在第二次和第三次复查时，关节疼痛的患病率总体上（分别为92%和68%的患者）以及在最常受累的五个关节中均逐渐下降。其他常见风湿症状和体征的患病率以及非甾体类抗炎药的使用在三次复查中也逐渐下降。
早期研究可能高估了RRV病症状的患病率和持续时间。在3至6个月内症状逐渐缓解似乎是常见情况。
