Mylonas Andrea D, Brown Allison M, Carthew Tracy L, McGrath Barry, Purdie David M, Pandeya Nirmala, Vecchio Philip C, Collins Louisa G, Gardner Ian D, de Looze Ferdinandus J, Reymond Elizabeth J, Suhrbier Andreas
Australian Centre for International Health and Nutrition, Queensland Institute of Medical Research, Post Office, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia.
Med J Aust. 2002 Oct 7;177(7):356-60. doi: 10.5694/j.1326-5377.2002.tb04837.x.
To describe the natural history, treatment and cost of Ross River virus-induced epidemic polyarthritis (RRV disease).
Questionnaire-based longitudinal prospective study.
Patients in the greater Brisbane area, Queensland, diagnosed with RRV disease by their general practitioners based on clinical symptoms and paired serological tests between November 1997 and April 1999.
Scores on two validated quality-of-life questionnaires (Clinical Health Assessment Questionnaire and Medical Outcomes Study Short Form 36) were obtained soon after diagnosis and one, two, three, six and 12 months thereafter. Scores were compared between patients diagnosed with RRV disease alone and those with RRV disease plus other conditions.
67 patients were enrolled. Most patients with RRV disease alone had severe acute symptoms, but followed a consistent path to recovery within three to six months. Other conditions, often chronic rheumatic diseases or depression, were identified in half the cohort; their quality-of-life scores suggested stable chronic illness between six and 12 months after diagnosis. Non-steroidal anti-inflammatory drugs (NSAIDs) were taken by 58% of patients (average use, 7.6 weeks; range, 2-22 weeks). Time off work averaged 1.9 days, and direct cost to the community was estimated as 1018 Australian dollars per patient.
Symptom duration and frequency of long-term symptoms may have been overestimated by previous studies of RRV disease. Disease persisting six to 12 months after RRV diagnosis was largely attributable to other conditions, highlighting the need to seek other diagnoses in RRV patients with persistent symptoms.
描述罗斯河病毒引起的流行性多关节炎（RRV病）的自然病史、治疗及费用情况。
基于问卷的纵向前瞻性研究。
1997年11月至1999年4月间，昆士兰州大布里斯班地区被全科医生根据临床症状及配对血清学检测诊断为RRV病的患者。
在确诊后不久以及之后1、2、3、6和12个月，获取两份经过验证的生活质量问卷（临床健康评估问卷和医学结局研究简表36）上的得分。比较单纯诊断为RRV病的患者与合并其他病症的RRV病患者的得分。
共纳入67例患者。大多数单纯RRV病患者有严重的急性症状，但在三到六个月内遵循一致的恢复路径。在一半的队列中发现了其他病症，通常是慢性风湿性疾病或抑郁症；他们的生活质量得分表明在诊断后六到十二个月之间为稳定的慢性病。58%的患者服用了非甾体抗炎药（NSAIDs）（平均用药时间7.6周；范围2 - 22周）。平均误工时间为1.9天，社区的直接成本估计为每位患者1018澳元。
先前关于RRV病的研究可能高估了症状持续时间和长期症状的发生率。RRV诊断后持续六到十二个月的疾病很大程度上归因于其他病症，这凸显了对有持续症状的RRV患者寻求其他诊断的必要性。
