Iimuro Masaki, Shibata Hideyuki, Kawamori Toshihiko, Matsumoto Takayuki, Arakawa Tetsuo, Sugimura Takashi, Wakabayashi Keiji
Cancer Prevention Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan.
Cancer Lett. 2002 Dec 10;187(1-2):61-8. doi: 10.1016/s0304-3835(02)00401-9.
Helicobacter pylori infection is intimately involved in stomach cancer development and recent epidemiological studies have indicated that the consumption of allium vegetables reduces the risk of gastric neoplasia. Therefore, in the present study, we investigated the effect of a garlic extract on H. pylori-induced gastritis in Mongolian gerbils. Garlic extract was fed to animals at doses of 1, 2 and 4% in the diet from 4 h after H. pylori inoculation until the end of the experiment, at week 6. With the administration of garlic extract, H. pylori-induced gastritis in animals was decreased in a dose-dependent manner, and significantly so at 4%. The numbers of hemorrhagic spots in the glandular stomach and the microscopic score for gastritis were significantly reduced from 19.2+/-15.6 and 5.9+/-0.8 in control gerbils to 8.1+/-11.2 and 4.2+/-1.5, respectively, by 4% garlic extract treatment. The stomach wet weight (1.04+/-0.22 g) of control gerbils was also reduced by 4% garlic extract (0.86+/-0.18 g). However, the number of viable H. pylori was not changed by the garlic extract treatment. The above observations indicated that garlic extract might be useful as an agent for prevention of H. pylori-induced gastritis, leading to reduction in the risk of gastric cancer.
幽门螺杆菌感染与胃癌的发生密切相关，最近的流行病学研究表明，食用葱属蔬菜可降低胃肿瘤的风险。因此，在本研究中，我们调查了大蒜提取物对蒙古沙鼠幽门螺杆菌诱导的胃炎的影响。从接种幽门螺杆菌后4小时开始，直到实验结束的第6周，以1%、2%和4%的剂量将大蒜提取物添加到动物饮食中。随着大蒜提取物的给予，动物中幽门螺杆菌诱导的胃炎呈剂量依赖性降低，4%剂量时降低显著。通过4%大蒜提取物处理，腺胃出血点数量和胃炎的显微镜评分分别从对照沙鼠的19.2±15.6和5.9±0.8显著降低至8.1±11.2和4.2±1.5。对照沙鼠的胃湿重（1.04±0.22 g）也因4%大蒜提取物而降低（0.86±0.18 g）。然而，大蒜提取物处理并未改变幽门螺杆菌的活菌数量。上述观察结果表明，大蒜提取物可能作为预防幽门螺杆菌诱导的胃炎的药物有用，从而降低胃癌风险。
