RNA诱导粗糙脉孢菌对肌醇的独立性
Induction by RNA of inositol independence in Neurospora crassa.
作者信息
Mishra N C, Niu M C, Tatum E L
出版信息
Proc Natl Acad Sci U S A. 1975 Feb;72(2):642-5. doi: 10.1073/pnas.72.2.642.
Abstract
The effect of purified wild-type RNA (allo-RNA) on genetic reversion of inositol-requiring mutant 89601 of Neurospora crassa is described. The mutant (inos minus) strain, on treatment with the wild-type RNA preparation, was found to revert to wild type (inos+) in significant numbers. RNA from the mutant (iso-RNA) and allo-RNA digested by RNase were ineffective in causing genetic reversion at the inositol locus. The allo-RNA-induced revertants were stable and showed a Mendelian transmission of the inos+ character.
摘要
描述了纯化的野生型RNA（同种RNA）对粗糙脉孢菌肌醇营养缺陷型突变体89601遗传回复突变的影响。发现用野生型RNA制剂处理的突变体（肌醇缺陷型）菌株大量回复为野生型（肌醇正常型）。来自突变体的RNA（同种RNA）和经核糖核酸酶消化的同种RNA在肌醇位点不能引起遗传回复突变。同种RNA诱导的回复突变体是稳定的，并且肌醇正常型性状呈现孟德尔式遗传。
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