Biswas B, Finbow J A
J Clin Pathol. 1975 Nov;28(11):905-9. doi: 10.1136/jcp.28.11.905.
The histological appearances in 114 endometrial curettings from cases of dysfunctional bleeding have been analysed quantitatively by the method of Dunnill and Whitehead (1972) and Risdon and Keeling (1974). As applied to this type of specimen, the technique provides indices of both tubular volume and tubular surface to volume ratio. The histological diagnosis of endometrial hyperplasia is made from the increase in stromal and epithelial elements and the change in the pattern of the glands. These changes, on some occasions, can be difficult to detect. Quantitative analysis can be used to distinguish minor degrees of abnormal endometrial hyperplasia, in comparing serial endometrial changes in a given patient, and in comparing different menstrual cycles in dysfunctional uterine bleeding. Endometrial biopsies were collected and put in categories according to the clinical diagnosis. These biopsies were then examined morphometrically to find the volume/glandular surface and glandular/volume ratio. A significant change in these ratios was found.
采用邓尼尔和怀特黑德（1972年）以及里斯登和基林（1974年）的方法，对114例功能失调性子宫出血病例的子宫内膜刮宫组织学表现进行了定量分析。应用于这类标本时，该技术可提供管腔体积以及管腔表面积与体积比的指标。子宫内膜增生的组织学诊断依据的是基质和上皮成分的增加以及腺体形态的改变。这些变化有时很难检测到。定量分析可用于区分轻度子宫内膜异常增生，比较特定患者的连续子宫内膜变化，以及比较功能失调性子宫出血患者不同月经周期的情况。收集子宫内膜活检组织，并根据临床诊断进行分类。然后对这些活检组织进行形态计量学检查，以确定体积/腺表面和腺体/体积比。发现这些比值有显著变化。
