Ammendola G, Di Rosa M, Sorrentino L
Agents Actions. 1975 Aug;5(3):250-5. doi: 10.1007/BF02026439.
The time course of rat carrageenin pleurisy has been studied. The inflammatory reaction is characterized by exudate formation and massive leucocyte emigration into the pleural space both reaching peak values at 24 hours. Moreover betaglucuronidase, acid phosphatase and lactic dehydrogenase have been assayed in the exudate. The activity of lysosomal enzymes parallels the severity of the inflammatory response, while that of cytoplasmic enzyme lactic dehydrogenase resulted unmodified. Treatment of animals with indomethacin, phenylbutazone, aspirin and flufenamic acid inhibited both exudate formation and leucocyte emigration. In contrast none of these drugs was able to reduce lysosomal enzyme release.
对大鼠角叉菜胶性胸膜炎的时间进程进行了研究。炎症反应的特征是渗出物形成以及大量白细胞移入胸膜腔，两者均在24小时达到峰值。此外，还测定了渗出液中的β-葡萄糖醛酸酶、酸性磷酸酶和乳酸脱氢酶。溶酶体酶的活性与炎症反应的严重程度平行，而细胞质酶乳酸脱氢酶的活性未发生改变。用吲哚美辛、保泰松、阿司匹林和氟芬那酸治疗动物可抑制渗出物形成和白细胞迁移。相比之下，这些药物均不能减少溶酶体酶的释放。
