Meacock S C, Kitchen E A
Agents Actions. 1976 Feb;6(1-3):320-5. doi: 10.1007/BF01972249.
The anti-inflammatory properties of 7 non-steroidal drugs have been examined in two animal models and one in vitro system. The models used were (1) carrageenin-induced paw oedema in rats previously depleted of polymorphonuclear cells, (2) carrageenin-induced rat pleurisy and (3) migration of rat peritoneal leucocytes from glass capillary tubes in vitro. All of the drugs suppressed oedema formation in rats depleted of polymorphonuclear cells. None affected the migration of polymorphonuclear cells into the inflamed pleural cavity. Four drugs suppressed the migration of mononuclear cells in the latter model. Of these, only phenylbutazone and indomethacin suppressed the random migration of leucocytes in vitro. It was concluded that the suppression of mononuclear cell migration is not a general property of non-steroidal anti-inflammatory drugs.
已在两种动物模型和一种体外系统中研究了7种非甾体药物的抗炎特性。所使用的模型为：（1）角叉菜胶诱导的多形核细胞已耗竭的大鼠爪部水肿；（2）角叉菜胶诱导的大鼠胸膜炎；（3）体外大鼠腹腔白细胞从玻璃毛细管的迁移。所有药物均抑制了多形核细胞已耗竭的大鼠的水肿形成。无一药物影响多形核细胞向炎症性胸膜腔的迁移。四种药物在后一种模型中抑制了单核细胞的迁移。其中，仅保泰松和吲哚美辛在体外抑制了白细胞的随机迁移。得出的结论是，抑制单核细胞迁移并非非甾体抗炎药的普遍特性。
