Metselaar J M, Mastrobattista E, Storm G
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (IUPS), Utrecht University, PO Box 80.082, The Netherlands.
Mini Rev Med Chem. 2002 Aug;2(4):319-29. doi: 10.2174/1389557023405873.
Drug targeting with liposomes has been studied for over 25 years and has demonstrated its value in clinical practice. This mini review offers an overview of the design and application of liposomes for i.v. drug targeting. Two approaches are outlined: passive and active targeting. The former approach is based on liposomes with prolonged circulation and selective target localization properties, while in the latter approach specific targeting ligands are coupled to the liposome surface in order to achieve enhanced interaction with target cell membranes.
脂质体药物靶向研究已超过25年，并在临床实践中展现出其价值。本综述概述了用于静脉内药物靶向的脂质体的设计与应用。文中概述了两种方法：被动靶向和主动靶向。前一种方法基于具有延长循环时间和选择性靶定位特性的脂质体，而在后一种方法中，特定的靶向配体与脂质体表面偶联，以实现与靶细胞膜更强的相互作用。
