Merzouk Hafida, Madani Sihem, Hichami Aziz, Prost Josiane, Moutairou Kabirou, Belleville Jacques, Khan Naim Akhtar
Laboratory of Animal Physiology, Tlemcen University, Algeria.
Lipids. 2002 Aug;37(8):773-81. doi: 10.1007/s11745-002-0960-9.
The time course of changes in lipoprotein metabolism of obese offspring of mildly diabetic rats was studied with respect to serum lipoprotein composition as well as LCAT and tissue lipoprotein lipase (LPL) activities. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, obese pups had higher serum glucose, insulin, and lipoprotein (VLDL, LDL-HDL1, HDL(2-3)) levels than control pups. After 1 mon of life, all of these parameters in obese rats became similar to those of controls. However, LCAT, adipose tissue LPL, and hepatic triacylglycerol lipase activities were high. At 2 mon of age, VLDL-TAG levels were higher in obese females than in controls. By the age of 3 mon, obese offspring had developed insulin resistance with hyperglycemia, hyperinsulinemia, and higher serum lipoprotein concentrations. Indeed, qualitative abnormalities of lipoproteins were seen and were typical of obese and diabetic human beings. Fetal hyperinsulinemia should be considered as a risk factor for later metabolic diseases, including dyslipoproteinemia.
就血清脂蛋白组成以及卵磷脂胆固醇酰基转移酶（LCAT）和组织脂蛋白脂肪酶（LPL）活性而言，研究了轻度糖尿病大鼠肥胖后代脂蛋白代谢的变化时间进程。在妊娠第5天通过腹腔注射链脲佐菌素诱导孕鼠出现轻度高血糖。对照孕鼠注射柠檬酸盐缓冲液。出生时，肥胖幼崽的血清葡萄糖、胰岛素和脂蛋白（极低密度脂蛋白、低密度脂蛋白 - 高密度脂蛋白1、高密度脂蛋白（2 - 3））水平高于对照幼崽。出生1个月后，肥胖大鼠的所有这些参数变得与对照大鼠相似。然而，LCAT、脂肪组织LPL和肝脏三酰甘油脂肪酶活性较高。在2个月大时，肥胖雌性大鼠的极低密度脂蛋白 - 甘油三酯水平高于对照大鼠。到3个月大时，肥胖后代出现了伴有高血糖、高胰岛素血症和更高血清脂蛋白浓度的胰岛素抵抗。事实上，观察到了脂蛋白的定性异常，这是肥胖和糖尿病患者的典型特征。胎儿高胰岛素血症应被视为包括血脂蛋白异常血症在内的后期代谢疾病的危险因素。
