Morse Zac, Kaizu Motoo, Sano Kimito, Kanri Tomio
Department of Anesthesiology, The Nippon Dental University at Niigata, Hamaura-cho, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Oct;94(4):420-4. doi: 10.1067/moe.2002.127587.
The purpose of this study was to determine whether the bispectral index scale (BIS) would provide added benefit to established methods of monitoring conscious sedation with midazolam (M group) or midazolam supplemented with ketamine (MK group).
BIS was prospectively and blindly examined in 22 patients receiving outpatient oral surgery with conscious sedation supplemented with local anesthesia.
The average midazolam dose in the midazolam group over the treatment period was 0.01 mg/kg/h, and the average midazolam plus ketamine dose was 0.01 and 0.05 mg/kg/h, respectively. Mean BIS values throughout the sedation study period were 90 for the midazolam group and 94 for the midazolam plus ketamine group. The addition of ketamine did not lower BIS. BIS values did not alter significantly over time except for an expected transient drop after the midazolam bolus induction.
BIS levels remained close to baseline levels, suggesting that BIS would not provided any additional benefit to currently established methods of monitoring patient consciousness during conscious sedation for oral surgery.
本研究旨在确定脑电双频指数（BIS）是否会为已确立的咪达唑仑监测清醒镇静方法（M组）或咪达唑仑联合氯胺酮监测方法（MK组）带来额外益处。
对22例接受门诊口腔手术并辅以局部麻醉的清醒镇静患者进行前瞻性、盲法脑电双频指数检测。
咪达唑仑组在治疗期间的平均咪达唑仑剂量为0.01mg/kg/h，咪达唑仑联合氯胺酮组的平均咪达唑仑和氯胺酮剂量分别为0.01mg/kg/h和0.05mg/kg/h。在整个镇静研究期间，咪达唑仑组的平均BIS值为90，咪达唑仑联合氯胺酮组为94。添加氯胺酮并未降低BIS值。除咪达唑仑推注诱导后预期的短暂下降外，BIS值随时间无显著变化。
BIS水平接近基线水平，表明BIS不会为目前已确立的口腔手术清醒镇静期间监测患者意识的方法带来任何额外益处。
