Klingström J, Heyman P, Escutenaire S, Sjölander K Brus, De Jaegere F, Henttonen H, Lundkvist A
Swedish Institute for Infectious Disease Control, Stockholm, Sweden.
J Med Virol. 2002 Dec;68(4):581-8. doi: 10.1002/jmv.10232.
In order to investigate rodent host specificity of European hantaviruses, experimental infection of colonized and wild-trapped rodents was performed. In addition to the natural rodent reservoir, Clethrionomys glareolus, Puumala hantavirus (PUUV) could infect colonized Microtus agrestis and Lemmus sibiricus, but not Syrian hamsters or Balb/C mice. Neither C. glareolus, nor M. agrestis, could be readily infected by Tula hantavirus (TULV). Wild-trapped Apodemus flavicollis and A. agrarius, the natural reservoirs of Dobrava (DOBV) and Saaremaa (SAAV) hantaviruses, respectively, could both be infected by SAAV. NMRI mice could also be infected by SAAV, but with lower efficiency as compared to Apodemus mice. Balb/C and NMRI laboratory mice, but not C. glareolus, could be infected by DOBV. To our knowledge, this is the first time DOBV and SAAV have been shown to infect adult laboratory mice. Moreover, potential hantavirus spillover infections were investigated in wild-trapped rodents. In addition to the natural host C. glareolus, we also found M. arvalis and A. sylvaticus with a history of PUUV infection. We did not find any C. glareolus or A. sylvaticus infected with TULV, a hantavirus which is known to circulate in the same geographical regions of Belgium.
为了研究欧洲汉坦病毒的啮齿动物宿主特异性，我们对圈养和野外捕获的啮齿动物进行了实验性感染。除了天然啮齿动物宿主棕背䶄外，普马拉汉坦病毒（PUUV）能够感染圈养的田鼠和西伯利亚旅鼠，但不能感染叙利亚仓鼠或Balb/C小鼠。无论是棕背䶄还是田鼠，都不容易被图拉汉坦病毒（TULV）感染。野外捕获的黄喉姬鼠和黑线姬鼠分别是多布拉瓦（DOBV）汉坦病毒和萨雷马（SAAV）汉坦病毒的天然宿主，它们都能被SAAV感染。NMRI小鼠也能被SAAV感染，但与姬鼠相比效率较低。Balb/C和NMRI实验室小鼠能被DOBV感染，但棕背䶄不能。据我们所知，这是首次证明DOBV和SAAV能感染成年实验室小鼠。此外，我们还对野外捕获的啮齿动物中潜在的汉坦病毒溢出感染进行了调查。除了天然宿主棕背䶄外，我们还发现了有PUUV感染史的小林姬鼠和林姬鼠。我们没有发现任何感染TULV的棕背䶄或林姬鼠，TULV是一种已知在比利时相同地理区域传播的汉坦病毒。
