Kim Sung Sook, Eom Daewoon, Huh Jooryung, Sung Iel-yong, Choi Inpyo, Ryu Sung Ho, Suh Pann Ghill, Chung Sung-Min
Department of Pathology, Medical School, University of Ulsan, Ulsan, Korea.
J Korean Med Sci. 2002 Oct;17(5):704-7. doi: 10.3346/jkms.2002.17.5.704.
We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C- gamma 1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.
我们报告了两例牙龈浆细胞肉芽肿病例，患者为两名男性肾移植受者，年龄分别为34岁和40岁，均有环孢素A（CsA）诱导的牙龈增生（GO）。组织学上，这些病变由成熟浆细胞组成，λ和κ轻链均显示多克隆性，并有纤维血管结缔组织基质。除了CsA诱导的浆细胞肉芽肿罕见这一事实外，我们病例的显著特征是肿瘤细胞分泌白细胞介素-6和磷脂酶C-γ1过表达，这可能解释了CsA诱导GO的机制。
