Pandav Amitkumar B, Gosavi Alka V, Lanjewar Dhaneshwar N, Jagadale Rakhi V
Department of Pathology, Government Medical College, Miraj, Maharashtra, India.
Dent Res J (Isfahan). 2012 Nov;9(6):816-20.
Plasma cell granuloma, also known as inflammatory pseudotumor is a tumor-like lesion that manifests primarily in the lungs. But it may occur in various other anatomic locations like orbit, head and neck, liver and rarely in the oral cavity. We here report an exceedingly rare case of gingival plasma cell granuloma in a 58 year old woman who presented with upper gingival polypoidal growth. The histopathological examination revealed a mass composed of proliferation of benign spindle mesenchymal cells in a loose myxoid and fibrocollagenous stroma along with dense infiltrate of chronic inflammatory cells predominantly containing plasma cells. Immunohistochemistry for kappa and lambda light chains showed a polyclonal staining pattern confirming a diagnosis of plasma cell granuloma.
浆细胞性肉芽肿，也称为炎性假瘤，是一种主要发生于肺部的肿瘤样病变。但它也可能出现在其他各种解剖部位，如眼眶、头颈部、肝脏，很少见于口腔。我们在此报告一例极为罕见的牙龈浆细胞性肉芽肿病例，患者为一名58岁女性，表现为上牙龈息肉样生长。组织病理学检查显示，肿块由良性梭形间充质细胞在疏松的黏液样和纤维胶原性基质中增殖形成，伴有以浆细胞为主的慢性炎性细胞密集浸润。κ和λ轻链的免疫组化显示多克隆染色模式，确诊为浆细胞性肉芽肿。
