肠外给予中链而非长链脂肪乳剂可能会增加白色念珠菌感染的风险。
Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans.
作者信息
Wanten Geert J, Netea Mihai G, Naber Ton H, Curfs Jo H, Jacobs Liesbeth E, Verver-Jansen Trees J, Kullberg Bart-Jan
机构信息
Department of Gastroenterology, University Medical Center Nijmegen, Nijmegen, The Netherlands.
出版信息
Infect Immun. 2002 Nov;70(11):6471-4. doi: 10.1128/IAI.70.11.6471-6474.2002.
Abstract
Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.
摘要
向志愿者静脉注射中链脂质乳剂（而非纯长链脂质乳剂或安慰剂），会增加血清中白色念珠菌的生长，并以一种表明中链甘油三酯（而非长链甘油三酯）会增加念珠菌感染风险的方式，调节念珠菌诱导的单核细胞细胞因子产生。
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2
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3
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4
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