Milazzo Mary Louise, Eyzaguirre Eduardo J, Molina Claudia P, Fulhorst Charles F
Department of Pathology and Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
J Infect Dis. 2002 Nov 15;186(10):1390-5. doi: 10.1086/344735. Epub 2002 Oct 29.
Hantavirus pulmonary syndrome (HPS) is a severe and often fatal rodent-borne zoonosis. Maporal (MAP) virus is a newly discovered hantavirus that originally was isolated from an arboreal rice rat captured in central Venezuela. The results of this study indicate that MAP virus in the Syrian golden hamster (Mesocricetus auratus) can cause a disease that is clinically and pathologically remarkably similar to HPS. The similarities include the time course of clinical disease, presence of virus-specific IgG at the onset of clinical disease, subacute pneumonitis, rapid onset of diffuse alveolar edema in the absence of necrosis, hepatic-portal triaditis, mononuclear-cellular infiltrate in lung and liver, widespread distribution of hantaviral antigen in endothelial cells of the microvasculature of lung and other tissues, and variable lethality. These similarities suggest that the MAP virus-hamster system is a useful model for studies of the pathogenesis of HPS and for the evaluation of potential therapeutic agents.
汉坦病毒肺综合征（HPS）是一种严重且往往致命的鼠传人畜共患病。马波拉尔（MAP）病毒是一种新发现的汉坦病毒，最初从委内瑞拉中部捕获的一只树栖稻鼠中分离出来。本研究结果表明，叙利亚金黄地鼠（Mesocricetus auratus）感染MAP病毒可引发一种疾病，在临床和病理上与HPS极为相似。相似之处包括临床疾病的病程、临床疾病发作时病毒特异性IgG的存在、亚急性肺炎、无坏死情况下弥漫性肺泡水肿的快速出现、肝门三联炎、肺和肝脏中的单核细胞浸润、汉坦病毒抗原在肺和其他组织微血管内皮细胞中的广泛分布以及不同的致死率。这些相似之处表明，MAP病毒-地鼠系统是研究HPS发病机制和评估潜在治疗药物的有用模型。
