Eyzaguirre Eduardo J, Milazzo Mary Louise, Koster Frederick T, Fulhorst Charles F
University of Texas Medical Branch, Department of Pathology, Galveston, Texas 77555-0609, USA.
Am J Trop Med Hyg. 2008 Apr;78(4):669-74.
Andes virus and Choclo virus are agents of hantavirus pulmonary syndrome. Andes virus in hamsters almost always causes a disease that is pathologically indistinguishable from fatal hantavirus pulmonary syndrome. The purpose of this study was to assess the pathogenicity of Choclo virus in hamsters. None of 18 hamsters infected with Choclo virus exhibited any symptom of disease. No evidence of inflammation or edema was found in the lungs of the 10 animals killed on days 7, 9, 11, 13, and 16 post-inoculation or in the lungs of the 8 animals killed on day 28 post-inoculation; however, hantavirus antigen was present in large numbers of endothelial cells in the microvasculature of the lungs of the animals killed on days 7, 9, 11, and 13 post-inoculation. These results suggest that infection in the microvasculature of lung tissue alone does not result in the life-threatening pulmonary edema in hamsters infected with Andes virus.
安第斯病毒和乔克洛病毒是汉坦病毒肺综合征的病原体。仓鼠感染安第斯病毒几乎总会引发一种疾病，其病理特征与致命性汉坦病毒肺综合征无法区分。本研究的目的是评估乔克洛病毒对仓鼠的致病性。18只感染乔克洛病毒的仓鼠均未表现出任何疾病症状。在接种后第7、9、11、13和16天处死的10只动物的肺部，以及接种后第28天处死的8只动物的肺部，均未发现炎症或水肿迹象；然而，在接种后第7、9、11和13天处死的动物肺部微血管中的大量内皮细胞中存在汉坦病毒抗原。这些结果表明，仅肺组织微血管感染不会导致感染安第斯病毒的仓鼠出现危及生命的肺水肿。
