Jutel Marek, Watanabe Takeshi, Akdis Mübeccel, Blaser Kurt, Akdis Cezmi A
Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland.
Curr Opin Immunol. 2002 Dec;14(6):735-40. doi: 10.1016/s0952-7915(02)00395-3.
Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions. In addition to its well-characterised effects in the acute inflammatory and allergic responses, histamine regulates several aspects of antigen-specific immune response development. Histamine affects the maturation of dendritic cells and alters their T cell-polarising capacity. Histamine also regulates antigen-specific T helper 1 and T helper 2 cells, as well as related antibody isotype responses. Apparently, diverse effects of histamine on immune regulation are because of differential expression of four types of histamine receptors and their distinct intracellular signals.
组胺是一种强效生物胺，在各种病理和生理条件下具有多种活性。除了在急性炎症和过敏反应中具有充分表征的作用外，组胺还调节抗原特异性免疫反应发展的多个方面。组胺影响树突状细胞的成熟并改变其T细胞极化能力。组胺还调节抗原特异性辅助性T细胞1和辅助性T细胞2，以及相关抗体亚型反应。显然，组胺对免疫调节的多种作用是由于四种组胺受体的差异表达及其独特的细胞内信号。
