Potkin Steven G, Anand Ravi, Alphs Larry, Fleming Kirsten
Department of Psychiatry and Human Behavior, University of California, Room 166, Irvine Hall, Irvine, CA 92697-3960, USA.
Schizophr Res. 2003 Jan 1;59(1):59-66. doi: 10.1016/s0920-9964(02)00159-7.
Almost 50% of schizophrenic persons attempt suicide at some time in their lives and 9-13% of patients ultimately commit suicide. While numerous studies have elucidated the relationship between psychiatric symptomatology and neurocognition in patients with schizophrenia, this is the first report, to our knowledge, to investigate the relationship between suicidal behavior and neurocognition in schizophrenia and schizoaffective disorder.
A subgroup of 188 patients participating in the InterSePT trial was assessed at baseline with an extensive neurocognitive battery and measures of suicidality and psychiatric symptomatology.
Measures of suicidality did not significantly correlate with neurocognitive performance. Confirmatory analyses between patients currently judged to be at high and low risk for suicide also revealed no neurocognitive differences. Consistent with previous studies, poor neurocognitive performance tended to be modestly correlated with the Positive and Negative Syndrome Rating Scale (PANSS) negative symptom scale. The relationship between suicidality and neurocognitive performance was similar for schizoaffective and schizophrenic patients.
The findings suggest that suicidality in patients with schizophrenia and schizoaffective disorder is not correlated with cognition and may, in fact, be a separate domain worthy of investigation and intervention.
近50%的精神分裂症患者在其生命中的某个时刻会尝试自杀，最终9 - 13%的患者会自杀身亡。虽然众多研究已经阐明了精神分裂症患者精神症状学与神经认知之间的关系，但据我们所知，这是首份调查精神分裂症和分裂情感性障碍患者自杀行为与神经认知之间关系的报告。
参与InterSePT试验的188名患者亚组在基线时接受了广泛的神经认知测试以及自杀倾向和精神症状学测量。
自杀倾向测量结果与神经认知表现无显著相关性。对目前判定为自杀高风险和低风险患者的验证性分析也未发现神经认知差异。与先前研究一致，较差的神经认知表现往往与阳性和阴性症状评定量表（PANSS）阴性症状量表存在适度相关性。分裂情感性障碍患者和精神分裂症患者的自杀倾向与神经认知表现之间的关系相似。
研究结果表明，精神分裂症和分裂情感性障碍患者的自杀倾向与认知无关，实际上可能是一个值得研究和干预的独立领域。
