Sukhin G M, Kovalev B N, Sinel'shchikova T A, Bergol'ts V M
Biull Eksp Biol Med. 1975 Dec;80(12):73-5.
The article treats of the effect of cyclophosphamide (CP), and complete Freund's adjuvant (CFA) and their combination on the development of transplantable leukemia-hemocytoblastosis in mice and some host humoral immune reactions. The optimal combinations of the CP (on the 3rd day after the transplantation of leukemia) and of the CFA (on the 10th day) led to increase in the average survival up to 93,9 days (8.5 days in control). This combination also increased the survival of 42.9% of the animals for over 180 days. Enhancement of humoral immunity proved to take place in the course of chemoimmunotherapy. In spite of deep immunodepression after the CP and CFA administration the number of antibody-producing cells increased and enhancement of the cytotoxic activity of the serum IgM was observed.
本文探讨了环磷酰胺（CP）、完全弗氏佐剂（CFA）及其联合使用对小鼠可移植性白血病-血细胞增多症发展的影响以及一些宿主体液免疫反应。CP（在白血病移植后第3天）和CFA（在第10天）的最佳组合使平均生存期延长至93.9天（对照组为8.5天）。这种组合还使42.9%的动物存活超过180天。在化学免疫治疗过程中证明体液免疫得到增强。尽管在给予CP和CFA后出现深度免疫抑制，但产生抗体的细胞数量增加，并且观察到血清IgM的细胞毒性活性增强。
