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Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions.

作者信息

Horwich Arthur

机构信息

Howard Hughes Medical Institute and Department Of Genetics, Yale University School Of Medicine, New Haven, Connecticut 06510, USA.

出版信息

J Clin Invest. 2002 Nov;110(9):1221-32. doi: 10.1172/JCI16781.

DOI:10.1172/JCI16781
PMID:12417558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC151620/
Abstract
摘要

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本文引用的文献

1
Electron microscopic observations on a fibrous component in amyloid of diverse origins.对不同来源淀粉样蛋白中一种纤维成分的电子显微镜观察。
Nature. 1959 Apr 25;183(4669):1202-3. doi: 10.1038/1831202a0.
2
Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy.α1-抗胰蛋白酶聚合与丝氨酸蛋白酶抑制剂病：病理生物学与治疗前景
J Clin Invest. 2002 Dec;110(11):1585-90. doi: 10.1172/JCI16782.
3
Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury.α1-抗胰蛋白酶缺乏症中的肝损伤：一种聚集蛋白诱导线粒体损伤。
J Clin Invest. 2002 Dec;110(11):1579-83. doi: 10.1172/JCI16787.
4
Orchestrating the unfolded protein response in health and disease.调控健康与疾病中的未折叠蛋白反应。
J Clin Invest. 2002 Nov;110(10):1389-98. doi: 10.1172/JCI16886.
5
Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.破解β淀粉样蛋白的起源与归宿可为阿尔茨海默病带来新的治疗方法。
J Clin Invest. 2002 Nov;110(10):1375-81. doi: 10.1172/JCI16783.
6
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.淀粉样β蛋白的天然分泌寡聚体在体内可有效抑制海马体长期增强效应。
Nature. 2002 Apr 4;416(6880):535-9. doi: 10.1038/416535a.
7
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases.聚集体的内在毒性意味着蛋白质错误折叠疾病存在共同机制。
Nature. 2002 Apr 4;416(6880):507-11. doi: 10.1038/416507a.
8
Kinetic partitioning of protein folding and aggregation.蛋白质折叠与聚集的动力学分配
Nat Struct Biol. 2002 Feb;9(2):137-43. doi: 10.1038/nsb752.
9
The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis.转甲状腺素蛋白的V122I心肌病变体增加了限速四聚体解离的速度，导致淀粉样变性加速。
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14943-8. doi: 10.1073/pnas.261419998.
10
Trans-suppression of misfolding in an amyloid disease.淀粉样疾病中错误折叠的反式抑制
Science. 2001 Sep 28;293(5539):2459-62. doi: 10.1126/science.1062245.