来自构树的天然蛋白酪氨酸磷酸酶1B抑制剂。

Natural PTP1B inhibitors from Broussonetia papyrifera.

作者信息

Chen Rong Min, Hu Li Hong, An Tian Ying, Li Jia, Shen Qiang

机构信息

Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.

出版信息

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3387-90. doi: 10.1016/s0960-894x(02)00757-6.

DOI:10.1016/s0960-894x(02)00757-6

PMID:12419367

Abstract

Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.

摘要

从构树根部分离得到两种新化合物，8-(1,1-二甲基烯丙基)-5'-(3-甲基丁-2-烯基)-3',4',5,7-四羟基黄酮醇（1）、3'-(3-甲基丁-2-烯基)-3',4',7-三羟基黄烷（2）以及三种已知化合物3,3',4',5,7-五羟基黄酮（3）、乌拉醇（4）、布罗索查酮A（5），并通过光谱方法确定了它们的结构。化合物1、3、4和5对蛋白酪氨酸磷酸酶1B（PTP1B）酶具有显著的抑制活性。