月桂中的杀锥虫萜类化合物

Trypanocidal terpenoids from Laurus nobilis L.

作者信息

Uchiyama Nahoko, Matsunaga Keiji, Kiuchi Fumiyuki, Honda Gisho, Tsubouchi Akiko, Nakajima-Shimada Junko, Aoki Takashi

机构信息

Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2002 Nov;50(11):1514-6. doi: 10.1248/cpb.50.1514.

DOI:10.1248/cpb.50.1514

PMID:12419922

Abstract

Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 microM, respectively.

摘要

对月桂（樟科）干叶的杀锥虫成分进行了研究。对甲醇提取物进行活性导向分级分离，得到两种愈创木烷型倍半萜内酯，脱氢木香内酯（1）和扎鲁扎宁D（2），以及一种新的对薄荷烷氢过氧化物，（1R，4S）-1-氢过氧基-对薄荷-2-烯-8-醇乙酸酯（3）。这些化合物对克氏锥虫前鞭毛体的最低致死浓度分别为6.3、2.5和1.4微摩尔。