来自喀什青兰的两种新单萜糖苷和杀锥虫萜类化合物。
Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi.
作者信息
Saeidnia Soodabeh, Gohari Ahmad Reza, Uchiyama Nahoko, Ito Michiho, Honda Gisho, Kiuchi Fumiyuki
机构信息
Department of Pharmacy, Faculty of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran.
出版信息
Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1249-50. doi: 10.1248/cpb.52.1249.
From the whole plant of Dracocephalum kotschyi BOISS., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1-8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), beta-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-beta-D-glucopyranoside (9), and limonen-10-ol 10-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (10). Compounds 1 (3.1 microM), 2 (3.1 microM), 3 (3.1 microM), 5 (6.2 microM), 6 (6.2 microM), and 8 (6.2 microM) were effective against epimastigotes of Trypanosoma cruzi.
从科氏青兰（Dracocephalum kotschyi BOISS.）的全株中分离出两种新的单萜糖苷（9, 10），以及七种已知的萜类化合物和一种植物甾醇（1 - 8）。它们的结构经确定分别为柠檬烯 - 10 - 醛（1）、香叶醛（2）、橙花醛（3）、β - 谷甾醇（4）、齐墩果酸（5）、熊果酸（6）、对 - 薄荷 - 8 - 烯 - 1,2 - 二醇（7）、科罗索酸（8）、柠檬烯 - 10 - 醇10 - O - β - D - 吡喃葡萄糖苷（9）和柠檬烯 - 10 - 醇10 - O - β - D - 吡喃葡萄糖基 - (1→2) - β - D - 吡喃葡萄糖苷（10）。化合物1（3.1微摩尔）、2（3.1微摩尔）、3（3.1微摩尔）、5（6.2微摩尔）、6（6.2微摩尔）和8（6.2微摩尔）对克氏锥虫的前鞭毛体有效。
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