Destoumieux-Garzón Delphine, Peduzzi Jean, Rebuffat Sylvie
Laboratoire de Chimie des Substances Naturelles, ESA 8041 CNRS, Muséum National d'Histoire Naturelle, 63, rue Buffon, 75231 Paris cedex 5, France.
Biochimie. 2002 May-Jun;84(5-6):511-9. doi: 10.1016/s0300-9084(02)01411-6.
Microcins are gene-encoded antimicrobial (poly)peptides secreted by Enterobacteriaceae. Produced under conditions of nutrient depletion, they are active against phylogenetically related microbial strains. Therefore, they are considered to play an important role in the microbial competitions within the intestinal flora. Among the limited sample of nine microcins hitherto described, a wide variety of structures and modes of action could be identified. The knowledge on microcins is very uneven, some being extensively studied, and others remaining uncharacterized. In this article, we have focused on a subgroup of highly modified microcins that show very original structures. We present an updated overview on the structures and mechanisms of action of microcins B17, C7 and J25, and on the associated effector proteins, also encoded by the microcin genetic system, which include specific modification enzymes, export proteins, and immunity factors.
微菌素是由肠杆菌科分泌的基因编码抗菌（多）肽。它们在营养物质耗尽的条件下产生，对系统发育相关的微生物菌株具有活性。因此，它们被认为在肠道菌群内的微生物竞争中发挥重要作用。在迄今描述的9种微菌素的有限样本中，可以鉴定出各种各样的结构和作用模式。关于微菌素的知识非常不均衡，一些已被广泛研究，而另一些仍未被表征。在本文中，我们重点关注了一组高度修饰的微菌素，它们具有非常独特的结构。我们提供了关于微菌素B17、C7和J25的结构、作用机制以及相关效应蛋白的最新概述，这些效应蛋白也由微菌素遗传系统编码，包括特定的修饰酶、输出蛋白和免疫因子。
