Pons Anne Marie, Lanneluc Isabelle, Cottenceau Gilles, Sable Sophie
Laboratoire de Génie Protéique et Cellulaire, Université de La Rochelle, Pôle Sciences, 17042 La Rochelle, cedex 1, France.
Biochimie. 2002 May-Jun;84(5-6):531-7. doi: 10.1016/s0300-9084(02)01416-5.
Microcins are a family of low molecular weight antibiotic peptides produced by Enterobacteriaceae strains and active against related bacteria. According to some features we propose to classify these antibiotic substances into two distinct groups. The class I microcins contain Mcc B17, C7, J25 and D93 that are small molecules (molecular mass inferior to 5 kDa), largely post-translationally modified and with specific intracellular targets. The class II microcins, MccV, E492, H47, L and 24, share several common properties with class IIa Gram-positive bacteriocins: molecular mass ranging from 7 to 10 kDa, absence of modified amino acids, double-glycine type leader peptides, secretion mediated by an ABC transporter and antibacterial activity due to interaction with bacterial membrane. This review discusses common features of the class II microcins and provides new insights into these peptides.
微菌素是一类由肠杆菌科菌株产生的低分子量抗生素肽，对相关细菌具有活性。根据一些特征，我们建议将这些抗生素物质分为两个不同的组。I类微菌素包含Mcc B17、C7、J25和D93，它们是小分子（分子量低于5 kDa），在很大程度上经过翻译后修饰，并且具有特定的细胞内靶点。II类微菌素MccV、E492、H47、L和24与IIa类革兰氏阳性细菌素具有几个共同特性：分子量范围为7至10 kDa，不存在修饰氨基酸，具有双甘氨酸型前导肽，由ABC转运蛋白介导分泌，以及由于与细菌膜相互作用而具有抗菌活性。本综述讨论了II类微菌素的共同特征，并提供了对这些肽的新见解。
