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One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT.

作者信息

Sun Xiao Bin, Kang Jian Xun, Zhao Yu Fen

机构信息

Key Laboratory of Bio-organic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084, China.

出版信息

Chem Commun (Camb). 2002 Oct 21(20):2414-5. doi: 10.1039/b207657h.

DOI:10.1039/b207657h
PMID:12430467
Abstract

A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.

摘要

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