左氧氟沙星滴眼液在人眼房水中的浓度水平。
Aqueous humor levels of topically applied levofloxacin in human eyes.
作者信息
Yamada Masakazu, Mochizuki Hiroshi, Yamada Kyoko, Kawai Masataka, Mashima Yukihiko
机构信息
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
出版信息
Curr Eye Res. 2002 May;24(5):403-6. doi: 10.1076/ceyr.24.5.403.8517.
PURPOSE
To evaluate transcorneal penetration of topically applied 0.5% levofloxacin into the aqueous humor in human eyes.
METHODS
Twenty cataract patients (14 females, 6 males) received 3 drops of 0.5% levofloxacin at 15 min intervals from 90 minutes before the surgery. At the beginning of the cataract surgery, 50 microL of aqueous humor was aspirated from the anterior chamber and stored at -80 degrees C until analysis. The drug concentration of the samples was analyzed using high-performance liquid chromatography.
RESULTS
A mean aqueous humor level of levofloxacin was 1.00 +/- 0.48 microg/mL (mean +/- standard deviation, n = 20), ranging from 0.30 microg/mL to 2.32 microg/mL.
CONCLUSIONS
The mean concentration of levofloxacin in the aqueous humor was higher than the MIC(90) values against some common pathogens of postoperative endophthalmitis, although a great degree of interpatient variability was present.
目的
评估局部应用0.5%左氧氟沙星后在人眼房水中的经角膜渗透情况。
方法
20例白内障患者（14例女性，6例男性）在手术前90分钟开始，每隔15分钟滴入3滴0.5%左氧氟沙星。在白内障手术开始时，从前房抽取50微升房水，储存在-80℃直至分析。使用高效液相色谱法分析样品的药物浓度。
结果
左氧氟沙星在房水中的平均水平为1.00±0.48微克/毫升（平均值±标准差，n = 20），范围为0.30微克/毫升至2.32微克/毫升。
结论
尽管患者间存在很大差异，但房水中左氧氟沙星的平均浓度高于针对一些常见术后眼内炎病原体的MIC(90)值。
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