Akbar Erum, Malik Abdul
International Center for Chemical Sciences, H.E.J Research Institute of Chemistry, University of Karachi, Pakistan.
Nat Prod Lett. 2002 Oct;16(5):339-44. doi: 10.1080/10575630290033088.
New triterpene, 3beta-(trans-cinnamoyloxy)-19alpha-hydroxy-urs-12-ene (1) has been isolated from the methanolic fraction of Debregeasia salicifolia, along with uvaol (2), 3beta,19alpha-dihydroxy-urs-12-ene (3), ursolic acid (4), pomolic acid (5), pomolic acid methyl ester (6) and tormentic acid (7) reported for the first time from this species. The compounds (1), (3) and (6) showed significant antimicrobial activity. The structure elucidation was made with the help of extensive 2D NMR spectroscopic techniques.
从水麻叶甲醇提取物中分离得到了新的三萜类化合物3β-(反式肉桂酰氧基)-19α-羟基乌苏-12-烯(1)，同时还分离得到了委陵菜酸(2)、3β,19α-二羟基乌苏-12-烯(3)、熊果酸(4)、坡模酸(5)、坡模酸甲酯(6)和 tormentic 酸(7)，其中化合物(6)是首次从该物种中报道。化合物(1)、(3)和(6)表现出显著的抗菌活性。借助广泛的二维核磁共振光谱技术对其结构进行了鉴定。
