bla(TEM)基因上游的启动子P3、Pa/Pb、P4和P5及其与β-内酰胺耐药性的关系。
Promoters P3, Pa/Pb, P4, and P5 upstream from bla(TEM) genes and their relationship to beta-lactam resistance.
作者信息
Lartigue Marie Frédérique, Leflon-Guibout Véronique, Poirel Laurent, Nordmann Patrice, Nicolas-Chanoine Marie-Hélène
机构信息
Service de Microbiologie-Hygiène, Hôpital Ambroise Paré Assistance Publique-Hôpitaux de Paris, Boulogne, France.
出版信息
Antimicrob Agents Chemother. 2002 Dec;46(12):4035-7. doi: 10.1128/AAC.46.12.4035-4037.2002.
Abstract
Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter P5, only found upstream of the bla(TEM-1B) gene, was related to the highest expression of this gene.
摘要
利用同基因系统，我们已确定已知控制bla(TEM)基因表达的四个启动子对β-内酰胺酶活性的影响。对于TEM-1和TEM-30，相对于相应基因上游启动子P3、Pa/Pb和P4的存在，这种活性逐渐增加。仅在bla(TEM-1B)基因上游发现的启动子P5与该基因的最高表达相关。
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本文引用的文献
1
[Antibiogram Committee of the French Microbiology Society. Report 2000-2001].[法国微生物学会抗菌谱委员会。2000 - 2001年报告]
Pathol Biol (Paris). 2000 Nov;48(9):832-71.
2
Updated sequence information and proposed nomenclature for bla(TEM) genes and their promoters.bla(TEM)基因及其启动子的更新序列信息和建议命名法。
Antimicrob Agents Chemother. 2000 Nov;44(11):3232-4. doi: 10.1128/AAC.44.11.3232-3234.2000.
3
Epidemiological survey of amoxicillin-clavulanate resistance and corresponding molecular mechanisms in Escherichia coli isolates in France: new genetic features of bla(TEM) genes.法国大肠杆菌分离株中阿莫西林-克拉维酸耐药性及其相应分子机制的流行病学调查：bla(TEM)基因的新遗传特征
Antimicrob Agents Chemother. 2000 Oct;44(10):2709-14. doi: 10.1128/AAC.44.10.2709-2714.2000.
4
Biochemical-genetic analysis and distribution of FAR-1, a class A beta-lactamase from Nocardia farcinica.来自豚鼠诺卡氏菌的A类β-内酰胺酶FAR-1的生化遗传分析及分布
Antimicrob Agents Chemother. 1999 Jul;43(7):1644-50. doi: 10.1128/AAC.43.7.1644.
5
Inhibitor-resistant TEM beta-lactamases: phenotypic, genetic and biochemical characteristics.耐抑制剂的 TEM β-内酰胺酶：表型、遗传和生化特征
J Antimicrob Chemother. 1999 Apr;43(4):447-58. doi: 10.1093/jac/43.4.447.
6
Updated sequence information for TEM beta-lactamase genes.TEM β-内酰胺酶基因的更新序列信息。
Antimicrob Agents Chemother. 1999 Feb;43(2):367-70. doi: 10.1128/AAC.43.2.367.
7
Two improved promoter sequences for the beta-lactamase expression arising from a single base-pair substitution.由单个碱基对替换产生的两种用于β-内酰胺酶表达的改进启动子序列。
Nucleic Acids Res. 1984 Apr 11;12(7):3219-34. doi: 10.1093/nar/12.7.3219.
8
McrA and McrB restriction phenotypes of some E. coli strains and implications for gene cloning.某些大肠杆菌菌株的McrA和McrB限制表型及其对基因克隆的影响。
Nucleic Acids Res. 1988 Feb 25;16(4):1563-75. doi: 10.1093/nar/16.4.1563.
9
Promoter selectivity of Escherichia coli RNA polymerase: effect of base substitutions in the promoter -35 region on promoter strength.大肠杆菌RNA聚合酶的启动子选择性：启动子 -35区域碱基替换对启动子强度的影响。
Nucleic Acids Res. 1990 Dec 25;18(24):7367-72. doi: 10.1093/nar/18.24.7367.
10
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.大肠杆菌质粒pBR322氨苄青霉素抗性基因的核苷酸序列。
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3737-41. doi: 10.1073/pnas.75.8.3737.
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