bla(TEM)基因及其启动子的更新序列信息和建议命名法。
Updated sequence information and proposed nomenclature for bla(TEM) genes and their promoters.
作者信息
Leflon-Guibout V, Heym B, Nicolas-Chanoine M
机构信息
Microbiology Department, Hôpital Ambroise-Paré, Université Paris V, 92100 Boulogne-Billancourt, France.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3232-4. doi: 10.1128/AAC.44.11.3232-3234.2000.
Abstract
The nucleotide sequences of 59 bla(TEM) genes encoding inhibitor-resistant TEM enzymes showed great genetic variability and were associated with different types of promoters. These findings led us to suggest an updated bla(TEM) gene nomenclature based on the origin of the bla(TEM) gene (bla(TEM-1A), bla(TEM-1B), bla(TEM-1C), bla(TEM-1D), bla(TEM-1E), and bla(TEM-1F)) and the promoter type.
摘要
59个编码对抑制剂耐药的TEM酶的bla(TEM)基因的核苷酸序列显示出很大的遗传变异性，并且与不同类型的启动子相关。这些发现促使我们基于bla(TEM)基因的起源（bla(TEM-1A)、bla(TEM-1B)、bla(TEM-1C)、bla(TEM-1D)、bla(TEM-1E)和bla(TEM-1F)）和启动子类型提出一个更新的bla(TEM)基因命名法。
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