Ludwig Mike, Sabatier Nancy, Dayanithi Govindan, Russell John A, Leng Gareth
Department of Biomedical Sciences, University of Edinburgh Medical School, George Square, Edinburgh EH8 9XD, UK.
Prog Brain Res. 2002;139:247-56. doi: 10.1016/s0079-6123(02)39021-6.
The interactions of the dendritically released neuropeptides vasopressin and oxytocin with co-released neuroactive substances such as opioids and nitric oxide are reviewed. Endogenous opioids regulate magnocellular neurons at the level of the supraoptic nucleus and the relationship of dendritically released peptides and co-released opioids seems to be dependent on the stimulus given and the physiological state of the animal. Nitric oxide has a prominent inhibitory action on supraoptic neurons and these actions are predominantly mediated indirectly by GABA inputs. The role of these co-released neuroactive substances in differentially regulated release of neuropeptides from dendrites versus distant axon terminals has to be determined in more detail. A picture emerges in which release of vasopressin and oxytocin from different anatomical compartments of a single neuron may arise from different intracellular secretory pools and their preparation before release.
本文综述了树突释放的神经肽血管加压素和催产素与共同释放的神经活性物质（如阿片类物质和一氧化氮）之间的相互作用。内源性阿片类物质在视上核水平调节大细胞神经元，树突释放的肽与共同释放的阿片类物质之间的关系似乎取决于给予的刺激和动物的生理状态。一氧化氮对视上神经元有显著的抑制作用，这些作用主要由GABA输入间接介导。这些共同释放的神经活性物质在差异调节树突与远处轴突终末神经肽释放中的作用，还有待更详细地确定。由此呈现出这样一种情况，即单个神经元不同解剖区域释放血管加压素和催产素，可能源于不同的细胞内分泌池及其释放前的准备过程。
